BCSC Extends Invasive Breast Cancer Model
The BCSC extends its invasive breast cancer risk model to include BMI, second-degree family history of breast cancer, and age at first live birth
The Breast Cancer Surveillance Consortium (BCSC) has extended its version 2 invasive breast cancer risk model to include body mass index (BMI), second-degree family history of breast cancer, and age at first live birth. The new version 3 model estimates a woman’s five- and ten-year risk of developing invasive breast cancer based on her age, race and ethnicity, first- and second-degree family history, breast density, history of benign breast biopsy, BMI, and age at first live birth.
Of the risk factors added to the model, BMI was associated with the largest improvement in risk estimation for individual women. Among women with an estimated 5-year risk of 3% or higher, the true-positive rate increased from 10.0% (version 2) to 19.8% (version 3) for women with BMI 30.0-34.9 kg/m2 and from 7.6% to 19.8% for women with BMI ≥35.0 kg/m2.
The BCSC invasive risk model is used by physicians to guide decisions about tailored screening and the use of risk-reducing medications. An online calculator and apps for both Apple and Android devices are being made available for use in clinical settings.
Gard CC, Tice JA, Miglioretti DL, Sprague BL, Bissell MCS, Henderson LM, Kerlikowske K. Extending the Breast Cancer Surveillance Consortium Model of Invasive Breast Cancer. J Clin Oncol. 2023 Nov 17:JCO2202470. doi: 10.1200/JCO.22.02470. Epub ahead of print. PMID: 37976443. [Link].
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Posted by: Charlotte Gard