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Statistical Coordinating Center for the Breast Cancer Surveillance Consortium - APRC Supplement

Grant number: U01CA086076-10S1
PI Name: Milgioretti D
Title: Statistical Coordinating Center for the Breast Cancer Surveillance Consortium - APRC Supplement

The goal of this proposal is to leverage the National Institute of Health’s (NIH) investment in three large trandisciplinary groups with the expertise and resources in breast cancer screening to accelerate research on the comparative effectiveness of film versus digital mammography screening in different subgroups of the U.S. population. The Statistical Coordinating Center of the BCSC is the parent grant for this proposal. The BCSC is a collaborative network of mammography registries with linkages to pathology and tumor data and contemporary data on film-screen and digital mammography from community-based facilities. The Cancer Intervention and Surveillance Modeling Network (CISNET) Breast Working Group and the Oregon Evidence-based Practice Center (EPC) will join the BCSC. CISNET has established breast cancer models that provide a strong platform for our research. EPC completed the last two evidence reviews of breast cancer screening for the US Preventive Services Task Force (USPSTF). We propose to bring these diverse collaborative units together with key members of the USPSTF to rapidly bridge evidence gaps in knowledge in breast cancer screening policy and to evaluate use of digital mammography. Our specific aims are to:

Aim 1: Bring collaborating partners together in an interactive two-day meeting forum to:

  1. obtain a consensus on our research agenda,
  2. ensure our research questions are framed in the most clinically and policy relevant manner,
  3. review data elements needed to address the questions,
  4. devise a work sharing plan carefully delineating synergistic roles, and
  5. agree on benchmarks and an evaluative process.

Aim 2: Combine information from the BCSC and EPC and selected CISNET models to compare the incremental effects of three breast cancer screening strategies with different starting ages and intervals (film vs. digital mammography vs. triage to mammography type based on breast density) and explore the impact of other factors (e.g., race) on results.

Aim 3: Re-convene in a final meeting to review the analysis results from Aim 2, discuss dissemination of results, evaluate the partnership activities, and develop future plans for new collaborative research.